Effects of dihydrotestosterone on cardiac inward rectifier K+ current
نویسندگان
چکیده
منابع مشابه
Revisit of the Cardiac Inward Rectifier Potassium Current IK1
Inward rectifier potassium currents are present in different types of cells. In the heart, the inward rectifier potassium current IK1 plays a crucial role in maintaining cardiac resting membrane potential and excitability. It is generally believed that the strong inward rectification of cardiac IK1 channels makes it conduct substantial current near the resting potential but carry little or no c...
متن کاملIon selectivity and current saturation in inward-rectifier K+ channels
We investigated the features of the inward-rectifier K channel Kir1.1 (ROMK) that underlie the saturation of currents through these channels as a function of permeant ion concentration. We compared values of maximal currents and apparent K(m) for three permeant ions: K(+), Rb(+), and NH(4)(+). Compared with K(+) (i(max) = 4.6 pA and K(m) = 10 mM at -100 mV), Rb(+) had a lower permeability, a lo...
متن کاملUnique Kir2.x properties determine regional and species differences in the cardiac inward rectifier K+ current.
The inwardly rectifying potassium (Kir) 2.x channels mediate the cardiac inward rectifier potassium current (I(K1)). In addition to differences in current density, atrial and ventricular I(K1) have differences in outward current profiles and in extracellular potassium ([K+]o) dependence. The whole-cell patch-clamp technique was used to study these properties in heterologously expressed Kir2.x c...
متن کاملSilent inward rectifier K+ channels in hypercholesterolemia.
Hypercholesterolemia is an independent risk factor for development of cardiovascular disease1 and has been demonstrated to impair endothelium-dependent and independent vasodilatation.2 However, the mechanisms responsible for changes in vascular reactivity and impaired blood flow regulation induced by hypercholesterolemia remain unclear. Previous studies in cultured endothelial cells have shown ...
متن کاملFluid flow facilitates inward rectifier K+ current by convectively restoring [K+] at the cell membrane surface
The inward rectifier Kir2.1 current (IKir2.1) was reported to be facilitated by fluid flow. However, the mechanism underlying this facilitation remains uncertain. We hypothesized that during K+ influx or efflux, [K+] adjacent to the outer mouth of the Kir2.1 channel might decrease or increase, respectively, compared with the average [K+] of the bulk extracellular solution, and that fluid flow c...
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ژورنال
عنوان ژورنال: International Journal of Andrology
سال: 2002
ISSN: 0105-6263,1365-2605
DOI: 10.1046/j.1365-2605.2002.00349.x